The Wim Hof Method Activate Your Full Human Pot...

The Wim Hof Method Activate Your Full Human Pot...

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An incredible book that might just change your life, but at the least your outlook. We get the backstory and amazing journey of the Iceman, Wim Hof, and also all the science behind his unique method. Hof lays out the guidelines for us all to take on a daily practice that will bring us happiness, health and strength. Driven by a desire to give everyone the tools to realise our best selves, this book is inspiring, compelling and motivating. Highly recommended.

INSTANT NEW YORK TIMES BESTSELLER The only definitive book authored by Wim Hof on his powerful method for realizing our physical and spiritual potential. \"This method is very simple, very accessible, and endorsed by science. Anybody can do it, and there is no dogma, only acceptance. Only freedom.\" --Wim HofWim Hof has a message for each of us: \"You can literally do the impossible. You can overcome disease, improve your mental health and physical performance, and even control your physiology so you can thrive in any stressful situation.\" With The Wim Hof Method, this trailblazer of human potential shares a method that anyone can use--young or old, sick or healthy--to supercharge their capacity for strength, vitality, and happiness. Wim has become known as \"The Iceman\" for his astounding physical feats, such as spending hours in freezing water and running barefoot marathons over deserts and ice fields. Yet his most remarkable achievement is not any record-breaking performance--it is the creation of a method that thousands of people have used to transform their lives. In his gripping and passionate style, Wim shares his method and his story, including: - Breath--Wim's unique practices to change your body chemistry, infuse yourself with energy, and focus your mind- Cold--Safe, controlled, shock-free practices for using cold exposure to enhance your cardiovascular system and awaken your body's untapped strength- Mindset--Build your willpower, inner clarity, sensory awareness, and innate joyfulness in the miracle of living- Science--How users of this method have redefined what is medically possible in study after study- Health--True stories and testimonials from people using the method to overcome disease and chronic illness- Performance--Increase your endurance, improve recovery time, up your mental game, and more- Wim's Story--Follow Wim's inspiring personal journey of discovery, tragedy, and triumph - Spiritual Awakening--How breath, cold, and mindset can reveal the beauty of your soul Wim Hof is a man on a mission: to transform the way we live by reminding us of our true power and purpose. \"This is how we will change the world, one soul at a time,\" Wim says. \"We alter the collective consciousness by awakening to our own boundless potential. We are limited only by the depth of our imagination and the strength of our conviction.\" If you're ready to explore and exceed the limits of your own potential, The Wim Hof Method is waiting for you.

The breathing protocol, which is composed of three to four rounds, takes about twenty minutes to complete. The best time to do these breathing exercises is before breakfast because when your stomach is full, all the metabolic activity and all the oxygen are directed to the stomach and block the way. This is logical because digestion is a function of the parasympathetic nervous system, and with the breathing, we are activating our sympathetic nervous system. The breathing ignites the body into an alert state, awakening the nervous system and preparing the body for performance. Eating beforehand can inhibit this physiological reaction.

For example, anyone can lift their right hand and scratch their nose with their index finger, but no one can fight bacteria that have been injected into their arm. Hof can do that. He can influence and control his autonomic nervous system. The autonomic nervous system regulates human functions such as body temperature, heart rate, blood pressure and breathing, and determines whether blood vessels should dilate or contract. In other words, the biological functions that happen in your body automatically.

Background Alcohol abuse is the second leading cause of dilated cardiomyopathy, a disorder specifically referred to as Alcoholic Cardiomyopathy (ACM). Rodent and human studies have revealed cardiac fibrosis to be a consequence of ACM and prior studies by this lab have associated this occurrence with elevated transforming growth factor-beta (TGF-β) and activated fibroblasts (myofibroblasts). To date there have been no other studies to investigate the direct effect of alcohol on the cardiac fibroblast. Methods Primary rat cardiac fibroblasts were cultured in the presence of ethanol and assayed for fibroblast activation by collagen gel contraction, alpha smooth muscle- actin (α-SMA) expression, migration, proliferation, apoptosis, collagen I & III and TGF-β expression. The TGF-β receptor type 1 inhibitor compound SB 431542 and a soluble recombinant TGF-βII receptor (RbII) were used to assess the role of of TGF-β in the response of cardiac fibroblasts to ethanol. Results Treatment of cardiac fibroblasts with ethanol at concentrations of 100 mg/dl or higher resulted in fibroblast activation and fibrogenic activity after 24 hours including an increase in contraction, α-SMA expression, migration, and expression of collagen I and TGF-β. No changes in fibroblast proliferation or apoptosis were observed. Inhibition of TGF-β by SB 431542 and RbII attenuated the ethanol-induced fibroblast activation. Conclusions Ethanol treatment directly promotes cardiac fibroblast activation by stimulating TGF-β release from fibroblasts. Inhibiting the action of TGF-β decreases the fibrogenic effect induced by ethanol treatment. The results of this study support TGF-β to be an important component in cardiac fibrosis induced by exposure to ethanol. PMID:23528014

Intermittent access (IA) to drugs of abuse, as opposed to continuous access, is hypothesized to induce a kindling-type transition from moderate to escalated use, leading to dependence. Intermittent 24-hour cycles of ethanol access and deprivation can generate high levels of voluntary ethanol drinking in rats. The current study uses C57BL/6J mice (B6) in an IA to 20% ethanol protocol to escalate ethanol drinking levels. Adult male and female B6 mice were given IA to 20% ethanol on alternating days of the week with water available ad libitum. Ethanol consumption during the initial 2 hours of access was compared with a short-term, limited access \"binge\" drinking procedure, similar to drinking-in-the-dark (DID). B6 mice were also assessed for ethanol dependence with handling-induced convulsion, a reliable measure of withdrawal severity. After 3 weeks, male mice given IA to ethanol achieved high stable levels of ethanol drinking in excess of 20 g/kg/24 h, reaching above 100 mg/dl blood ethanol concentrations, and showed a significantly higher ethanol preference than mice given continuous access to ethanol. Also, mice given IA drank about twice as much as DID mice in the initial 2-hour access period. B6 mice that underwent the IA protocol for longer periods of time displayed more severe signs of alcohol withdrawal. Additionally, female B6 mice were given IA to ethanol and drank significantly more than males (ca. 30 g/kg/24 h). The IA method in B6 mice is advantageous because it induces escalated, voluntary, and preferential per os ethanol intake, behavior that may mimic a cardinal feature of human alcohol dependence, though the exact nature and site of ethanol acting in the brain and blood as a result of IA has yet to be determined. Copyright 2011 by the Research Society on Alcoholism.

With the development of opioid abuse-deterrent formulations (ADFs), there is a need to conduct well-designed human abuse potential studies to evaluate the effectiveness of their deterrent properties. Although these types of studies have been conducted for many years, largely to evaluate inherent abuse potential of a molecule and inform drug scheduling, methodological approaches have varied across studies. The focus of this review is to describe current \"best practices\" and methodological adaptations required to assess abuse-deterrent opioid formulations for regulatory submissions. A literature search was conducted in PubMed to review methodological approaches (study conduct and analysis) used in opioid human abuse potential studies. Search terms included a combination of \"opioid,\" \"opiate,\" \"abuse potential,\" \"abuse liability,\" \"liking,\" AND \"pharmacodynamic,\" and only studies that evaluated single doses of opioids in healthy, nondependent individuals with or without prior opioid experience were included. Seventy-one human abuse potential studies meeting the prespecified criteria were identified, of which 21 studies evaluated a purported opioid ADF. Based on these studies, key methodological considerations were reviewed and summarized according to participant demographics, study prequalification, comparator and dose selection, route of administration and drug manipulation, study blinding, outcome measures and training, safety, and statistical analyses. The authors recommend careful consideration of key elements (eg, a standardized definition of a \"nondependent recreational user\"), as applicable, and offer key principles and \"best practices\" when conducting human abuse potential studies for opioid ADFs. Careful selection of appropriate study conditions is dependent on the type of ADF technology being evaluated. 59ce067264

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