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In the last several years, a growing body of scientific evidence has indicated that the air within homes and other buildings can be more seriously polluted than the outdoor air in even the largest and most industrialized cities. Other research indicates that people spend approximately 90% of their time indoors. Thus, for many people, the risks to health from exposure to indoor air pollution may be greater than risks from outdoor pollution.

Biologic PollutantsBiologic pollutants include bacteria, molds, viruses, animal dander, cat saliva, dust mites, cockroaches, and pollen. These biologic pollutants can be related to some serious health effects. Some biologic pollutants, such as measles, chickenpox, and influenza are transmitted through the air. However, the first two are now preventable with vaccines. Influenza virus transmission, although vaccines have been developed, still remains of concern in crowded indoor conditions and can be affected by ventilation levels in the home.

HEPA vacuums are now widely available and have also been shown to be effective [8]. A conventional vacuum tends to be inefficient as a control measure and results in a significant increase in airborne dust concentrations, but can be used with multilayer microfiltration collection bags. Another approach to mite control is reducing indoor humidity to below 50% and installing central air conditioning.

Toxics and Irritants. Many molds also produce mycotoxins that can be a health hazard on ingestion, dermal contact, or inhalation [14]. Although common outdoor molds present in ambient air, such as Cladosporium cladosporioides and Alternaria alternata, do not usually produce toxins, many other different mold species do [17]. Genera-producing fungi associated with wet buildings, such as Aspergillus versicolor, Fusarium verticillioides, Penicillium aiurantiorisen, and S. chartarum, can produce potent toxins [17]. A single mold species may produce several different toxins, and a given mycotoxin may be produced by more than one species of fungi. Furthermore, toxin-producing fungi do not necessarily produce mycotoxins under all growth conditions, with production being dependent on the substrate it is metabolizing, temperature, water content, and humidity [17]. Because species of toxin-producing molds generally have a higher water requirement than do common household molds, they tend to thrive only under conditions of chronic and severe water damage [18]. For example, Stachybotrys typically only grows under continuously wet conditions [19]. It has been suggested that very young children may be especially vulnerable to certain mycotoxins [19, 20]. For example, associations have been reported for pulmonary hemorrhage (bleeding lung) deaths in infants and the presence of S. chartarum [21,22,23, 24]. Causes of Mold. Mold growth can be caused by any condition resulting in excess moisture. Common moisture sources include rain leaks (e.g., on roofs and wall joints); surface and groundwater leaks (e.g., poorly designed or clogged rain gutters and footing drains, basement leaks); plumbing leaks; and stagnant water in appliances (e.g., dehumidifiers, dishwashers, refrigerator drip pans, and condensing coils and drip pans in HVAC systems). Moisture problems can also be due to water vapor migration and condensation problems, including uneven indoor temperatures, poor air circulation, soil air entry into basements, contact of humid unconditioned air with cooled interior surfaces, and poor insulation on indoor chilled surfaces (e.g., chilled water lines). Problems can also be caused by the production of excess moisture within homes from humidifiers, unvented clothes dryers, overcrowding, etc. Finished basements are particularly susceptible to mold problems caused by the combination of poorly controlled moisture and mold-supporting materials (e.g., carpet, paper-backed sheetrock) [15]. There is also some evidence that mold spores from damp or wet crawl spaces can be transported through air currents into the upper living quarters. Older, substandard housing low income families can be particularly prone to mold problems because of inadequate maintenance (e.g., inoperable gutters, basement and roof leaks), overcrowding, inadequate insulation, lack of air conditioning, and poor heating. Low interior temperatures (e.g., when one or two rooms are left unheated) result in an increase in the relative humidity, increasing the potential for water to condense on cold surfaces.

For routine assessments in which the goal is to identify possible mold contamination problems before remediation, it is usually unnecessary to collect and analyze air or settled dust samples for mold analysis because decisions about appropriate intervention strategies can typically be made on the basis of a visual inspection [25]. Also, sampling and analysis costs can be relatively high and the interpretation of results is not straightforward. Air and dust monitoring may, however, be necessary in certain situations, including 1) if an individual has been diagnosed with a disease associated with fungal exposure through inhalation, 2) if it is suspected that the ventilation systems are contaminated, or 3) if the presence of mold is suspected but cannot be identified by a visual inspection or bulk sampling [26]. Generally, indoor environments contain large reservoirs of mold spores in settled dust and contaminated building materials, of which only a rel